Deputy skipper Andre Ayew and his brother Jordan Ayew have been excluded from the squad with Daniel Amartey of Leicester City.
Two Ghana Premier League stars Daniel Darkwah and Asante Kotoko goalie Felix Annan have been dropped.
Torino midfielder Afriyie Acquah and Thomas Partey have also been excluded from the squad.
In-form Gershon Koffie of MLS side New England Revolution has been handed a call-up with Kwadwo Poku and Mohammed Abu
Below is the Ghana squad for Mexico/USA friendlies
Richard Ofori (Wa All Stars) and Addo Joseph (Aduana Stars)
Harrison Afful (Columbus Crew), Nicholas Opoku (Berekum Chelsea), Lumor Agbenyenu (Munich 1860, Germany), John Boye (Sivasspor, Turkey), Rashid Sumalia (Al Gharafa, Qatar), Jonathan Mensah (Columbus Crew, USA), Jerry Akaminko ( Eskiserhispor, Turkey), Samuel Sarfo (Liberty, Ghana)
Mohammed Abu (Columbus Crew, USA), Isaac Sackey (Alanyaspor, Turkey), Ofori Ebenezer (Stuttgart, Germany), Winful Kwaku Cobbinah (Hearts of Oak), Frank Acheampong (Anderlecht, Belgium), Thomas Agyepong (NAC Breda, Holland)
Asamoah Gyan (Al Alhi, UAE), Majeed Abdul Waris (Lorient FC, France), Raphael Dwamena (FC Zurich, Switzerland), Kwadwo Poku (FC Miami), David Accam (Chicago Fires), Gershon Koffie (New England Revolution)